ocr: 3.4 Cholesterol Modifying Medications - continued These medications are always mixed with water or food. The resins commonly cause stomach upset and constipation. Always take the resins 1 hour before or 4 hours after taking other medications. This prevents the resins from binding to other medications. Niacin or nicotinic acid (not niacinamide) is one of the most ettective agents for increasing HDL cholesterol levels. Flushing and itching commonly occur on initial use of niacin. Dosing should start low and increase gradually to reduce developing side effects. Ad dose of ASA 325 mg taken 30 minu ...